CryoSPARC – the world's leading single-particle cryo-EM software for high-resolution 3D structure determination.https://cryosparc.com/en-ushttps://cryosparc.com/blog/case-study-11631-and-11632/https://cryosparc.com/blog/case-study-11631-and-11632/Using a controlled FaNaC1 dataset, we compared 3D Classification, Heterogeneous Refinement, 3D Variability Analysis, and 3D Flexibility Analysis to explore practical strategies for resolving both discrete and continuous heterogeneity in cryo-EM.Thu, 13 Aug 2026 00:00:00 GMTCase Studiesstructural-biologycryosparccryo-emheterogeneitycase-studyCryoSPARC Teamhttps://cryosparc.com/blog/tubulin/https://cryosparc.com/blog/tubulin/By capturing transient β-tubulin-bound intermediates with cryo-EM, researchers reconstructed the molecular mechanism of α/β-tubulin biogenesis, explaining how mutations in the assembly machinery lead to tubulin biogenesis disorders.Thu, 30 Jul 2026 00:00:00 GMTDiscoveriesstructural-biologycryosparccryo-emdiscoveriesCryoSPARC Teamhttps://cryosparc.com/blog/parameters-3d-refinement/https://cryosparc.com/blog/parameters-3d-refinement/The effect of parameter settings on 3D refinement: Minimize over per-particle scale, Adaptive marginalization, Non-uniform regularization, and MaskingTue, 21 Jul 2026 00:00:00 GMTDigging deepercryosparccryo-emrefinementmethodsworkflowcase-studyCryoSPARC Teamhttps://cryosparc.com/blog/gap-junctions/https://cryosparc.com/blog/gap-junctions/Using single particle cryo-EM on plaque-mimicking nanodiscs, researchers determined multiple connexin assembly states and uncovered lipid-protein interactions that may help understand gap junction organization and function.Wed, 08 Jul 2026 00:00:00 GMTDiscoveriesstructural-biologycryosparccryo-emdiscoveriesCryoSPARC Teamhttps://cryosparc.com/blog/automated-data-processing/https://cryosparc.com/blog/automated-data-processing/How to make use of one-click, automated data processing workflows that can provide equal or better results as manual processingThu, 25 Jun 2026 00:00:00 GMTAutomated Workflowsstructural-biologycryosparccryo-emautomated-workflowsgpcrCryoSPARC Teamhttps://cryosparc.com/blog/kor-sbdd/https://cryosparc.com/blog/kor-sbdd/Cryo-EM revealed the molecular basis of KOR signaling bias, enabling structure-based drug design of an anti-pruritic peptide with reduced side effects.Tue, 16 Jun 2026 00:00:00 GMTDiscoveriesstructural-biologycryosparccryo-emdiscoveriessbddgpcrCryoSPARC Teamhttps://cryosparc.com/blog/case-study-10927/https://cryosparc.com/blog/case-study-10927/From active and deactive states to additional respiratory complexes, this case study shows how a single cryo-EM dataset can tell many different stories when viewed through the lens of heterogeneity.Tue, 09 Jun 2026 00:00:00 GMTCase Studiesstructural-biologycryosparccryo-emheterogeneitycase-studyCryoSPARC Teamhttps://cryosparc.com/blog/measles/https://cryosparc.com/blog/measles/How Cryo-EM allows a closer look at the Human neutralizing antibodies targeting the measles virusFri, 05 Jun 2026 00:00:00 GMTDiscoveriesstructural-biologycryosparcdiscoveriescryo-emCryoSPARC Teamhttps://cryosparc.com/blog/high-resolution-ab-initio-reconstruction/https://cryosparc.com/blog/high-resolution-ab-initio-reconstruction/High-Resolution Ab-Initio Reconstruction: Extending Cryo-EM to Smaller Particles with CryoSPARC™Wed, 27 May 2026 00:00:00 GMTSmall Protein Targetsstructural-biologycryosparccryo-emsmall-proteinCryoSPARC Teamhttps://cryosparc.com/blog/v5-0-stable-release/https://cryosparc.com/blog/v5-0-stable-release/Explore the new features, expanded capabilities, and a more intuitive processing experience!Wed, 27 May 2026 00:00:00 GMTCryoSPARC Updatesstructural-biologycryosparcreleaseoverviewcryo-emCryoSPARC Team