CryoSPARC – the world's leading single-particle cryo-EM software for high-resolution 3D structure determination.https://cryosparc.com/en-ushttps://cryosparc.com/blog/curation-picking/https://cryosparc.com/blog/curation-picking/Digging into Sections 1 to 4 of one of our CryoSPARC case studies, we explore strategies for streamlining preprocessing and particle curation, using tools such as Micrograph Junk Detector and Micrograph Denoiser to efficiently move from initial micrographs to a curated particle set.Thu, 10 Sep 2026 00:00:00 GMTDigging deepercase-studycryo-emcryosparcmethodsstructural-biologyworkflowCryoSPARC Teamhttps://cryosparc.com/blog/trpv1-msp20/https://cryosparc.com/blog/trpv1-msp20/Combining rational drug design, functional studies, and cryo-EM, researchers characterize a selective TRPV1 agonist that promotes desensitization and prolonged pain relief.Tue, 01 Sep 2026 00:00:00 GMTDiscoveriesstructural-biologycryosparccryo-emdiscoveriessbddCryoSPARC Teamhttps://cryosparc.com/blog/instance-recovery-v5/https://cryosparc.com/blog/instance-recovery-v5/Discover the Instance Recovery feature introduced in CryoSPARC v5: how to recover a CryoSPARC instance if the database directory is corrupted or lost.Thu, 27 Aug 2026 00:00:00 GMTCryoSPARC Updatesit-managementcryo-emcryosparcoverviewreleaseCryoSPARC Teamhttps://cryosparc.com/blog/malaria/https://cryosparc.com/blog/malaria/Using single-particle cryo-EM, researchers revealed how the malaria parasite's moving junction remodels host membranes and used its native structure to guide the design of a protein inhibitor of parasite invasion.Thu, 20 Aug 2026 00:00:00 GMTDiscoveriesstructural-biologycryosparccryo-emdiscoveriessbddCryoSPARC Teamhttps://cryosparc.com/blog/case-study-11631-and-11632/https://cryosparc.com/blog/case-study-11631-and-11632/Using a controlled FaNaC1 dataset, we compared 3D Classification, Heterogeneous Refinement, 3D Variability Analysis, and 3D Flexibility Analysis to explore practical strategies for resolving both discrete and continuous heterogeneity in cryo-EM.Thu, 13 Aug 2026 00:00:00 GMTCase Studiesstructural-biologycryosparccryo-emheterogeneitycase-studyCryoSPARC Teamhttps://cryosparc.com/blog/tubulin/https://cryosparc.com/blog/tubulin/By capturing transient β-tubulin-bound intermediates with cryo-EM, researchers reconstructed the molecular mechanism of α/β-tubulin biogenesis, explaining how mutations in the assembly machinery lead to tubulin biogenesis disorders.Thu, 30 Jul 2026 00:00:00 GMTDiscoveriesstructural-biologycryosparccryo-emdiscoveriesCryoSPARC Teamhttps://cryosparc.com/blog/parameters-3d-refinement/https://cryosparc.com/blog/parameters-3d-refinement/The effect of parameter settings on 3D refinement: Minimize over per-particle scale, Adaptive marginalization, Non-uniform regularization, and MaskingTue, 21 Jul 2026 00:00:00 GMTDigging deepercryosparccryo-emrefinementmethodsworkflowcase-studyCryoSPARC Teamhttps://cryosparc.com/blog/gap-junctions/https://cryosparc.com/blog/gap-junctions/Using single particle cryo-EM on plaque-mimicking nanodiscs, researchers determined multiple connexin assembly states and uncovered lipid-protein interactions that may help understand gap junction organization and function.Wed, 08 Jul 2026 00:00:00 GMTDiscoveriesstructural-biologycryosparccryo-emdiscoveriesCryoSPARC Teamhttps://cryosparc.com/blog/automated-data-processing/https://cryosparc.com/blog/automated-data-processing/How to make use of one-click, automated data processing workflows that can provide equal or better results as manual processingThu, 25 Jun 2026 00:00:00 GMTAutomated Workflowsstructural-biologycryosparccryo-emautomated-workflowsgpcrCryoSPARC Teamhttps://cryosparc.com/blog/kor-sbdd/https://cryosparc.com/blog/kor-sbdd/Cryo-EM revealed the molecular basis of KOR signaling bias, enabling structure-based drug design of an anti-pruritic peptide with reduced side effects.Tue, 16 Jun 2026 00:00:00 GMTDiscoveriesstructural-biologycryosparccryo-emdiscoveriessbddgpcrCryoSPARC Teamhttps://cryosparc.com/blog/case-study-10927/https://cryosparc.com/blog/case-study-10927/From active and deactive states to additional respiratory complexes, this case study shows how a single cryo-EM dataset can tell many different stories when viewed through the lens of heterogeneity.Tue, 09 Jun 2026 00:00:00 GMTCase Studiesstructural-biologycryosparccryo-emheterogeneitycase-studyCryoSPARC Teamhttps://cryosparc.com/blog/measles/https://cryosparc.com/blog/measles/How Cryo-EM allows a closer look at the Human neutralizing antibodies targeting the measles virusFri, 05 Jun 2026 00:00:00 GMTDiscoveriesstructural-biologycryosparcdiscoveriescryo-emCryoSPARC Teamhttps://cryosparc.com/blog/high-resolution-ab-initio-reconstruction/https://cryosparc.com/blog/high-resolution-ab-initio-reconstruction/High-Resolution Ab-Initio Reconstruction: Extending Cryo-EM to Smaller Particles with CryoSPARC™Wed, 27 May 2026 00:00:00 GMTSmall Protein Targetsstructural-biologycryosparccryo-emsmall-proteinCryoSPARC Teamhttps://cryosparc.com/blog/v5-0-stable-release/https://cryosparc.com/blog/v5-0-stable-release/Explore the new features, expanded capabilities, and a more intuitive processing experience!Wed, 27 May 2026 00:00:00 GMTCryoSPARC Updatesstructural-biologycryosparcreleaseoverviewcryo-emCryoSPARC Team