DiscoveriesThe Pain Paradox: Activating TRPV1 to Silence Its ResponseCombining rational drug design, functional studies, and cryo-EM, researchers characterize a selective TRPV1 agonist that promotes desensitization and prolonged pain relief.#structural-biology#cryosparc#cryo-em#discoveries#sbddCryoSPARC Team·September 1, 2026
DiscoveriesMalaria Invasion at Molecular Resolution: From Protein Inhibitors to Membrane RemodelingUsing single-particle cryo-EM, researchers revealed how the malaria parasite's moving junction remodels host membranes and used its native structure to guide the design of a protein inhibitor of parasite invasion.#structural-biology#cryosparc#cryo-em#discoveries#sbddCryoSPARC Team·August 20, 2026
DiscoveriesScratching Beneath the Surface: Cryo-EM Guides New Opioid Drug DesignCryo-EM revealed the molecular basis of KOR signaling bias, enabling structure-based drug design of an anti-pruritic peptide with reduced side effects.#structural-biology#cryosparc#cryo-em#discoveries#sbdd#gpcrCryoSPARC Team·June 16, 2026
