Automated WorkflowsOvercoming Preferred Orientation with Automated Workflows in CryoSPARC™Preferred orientation is a persistent challenge in cryo-EM, but what can be done during data processing? Explore how advanced automated workflows in CryoSPARC can mitigate the effects of preferred orientation, improving map quality and interpretability across nine challenging datasets.#automated-workflows#cryo-em#cryosparc#sbdd#structural-biologyCryoSPARC Team·October 28, 2026
DiscoveriesThe Pain Paradox: Activating TRPV1 to Silence Its ResponseCombining rational drug design, functional studies, and cryo-EM, researchers characterize a selective TRPV1 agonist that promotes desensitization and prolonged pain relief.#structural-biology#cryosparc#cryo-em#discoveries#sbddCryoSPARC Team·September 1, 2026
DiscoveriesMalaria Invasion at Molecular Resolution: From Protein Inhibitors to Membrane RemodelingUsing single-particle cryo-EM, researchers revealed how the malaria parasite's moving junction remodels host membranes and used its native structure to guide the design of a protein inhibitor of parasite invasion.#structural-biology#cryosparc#cryo-em#discoveries#sbddCryoSPARC Team·August 20, 2026
DiscoveriesScratching Beneath the Surface: Cryo-EM Guides New Opioid Drug DesignCryo-EM revealed the molecular basis of KOR signaling bias, enabling structure-based drug design of an anti-pruritic peptide with reduced side effects.#structural-biology#cryosparc#cryo-em#discoveries#sbdd#gpcrCryoSPARC Team·June 16, 2026
