#cryosparc

13 posts with this tag.

The Pain Paradox: Activating TRPV1 to Silence Its Response

Combining rational drug design, functional studies, and cryo-EM, researchers characterize a selective TRPV1 agonist that promotes desensitization and prolonged pain relief.

#structural-biology #cryosparc #cryo-em #discoveries #sbdd

CryoSPARC Team

·September 1, 2026

CryoSPARC Updates

Instance Recovery in CryoSPARC v5

Discover the Instance Recovery feature introduced in CryoSPARC v5: how to recover a CryoSPARC instance if the database directory is corrupted or lost.

#it-management #cryo-em #cryosparc #overview #release

CryoSPARC Team

·August 27, 2026

Discoveries

Malaria Invasion at Molecular Resolution: From Protein Inhibitors to Membrane Remodeling

Using single-particle cryo-EM, researchers revealed how the malaria parasite's moving junction remodels host membranes and used its native structure to guide the design of a protein inhibitor of parasite invasion.

#structural-biology #cryosparc #cryo-em #discoveries #sbdd

CryoSPARC Team

·August 20, 2026

Case Studies

Mixing Two Cryo-EM Datasets on Purpose: A Cryo-EM Heterogeneity Challenge

Using a controlled FaNaC1 dataset, we compared 3D Classification, Heterogeneous Refinement, 3D Variability Analysis, and 3D Flexibility Analysis to explore practical strategies for resolving both discrete and continuous heterogeneity in cryo-EM.

#structural-biology #cryosparc #cryo-em #heterogeneity #case-study

CryoSPARC Team

·August 13, 2026

Discoveries

Cryo-EM Reveals the Molecular Machinery of Tubulin Assembly

By capturing transient β-tubulin-bound intermediates with cryo-EM, researchers reconstructed the molecular mechanism of α/β-tubulin biogenesis, explaining how mutations in the assembly machinery lead to tubulin biogenesis disorders.

#structural-biology #cryosparc #cryo-em #discoveries

CryoSPARC Team

·July 30, 2026

Digging deeper

Digging Deeper: Why refinements can be robust to the presence of junk particles

The effect of parameter settings on 3D refinement: Minimize over per-particle scale, Adaptive marginalization, Non-uniform regularization, and Masking

#cryosparc #cryo-em #refinement #methods #workflow #case-study

CryoSPARC Team

·July 21, 2026

Discoveries

Mind The Gap: Cryo-EM Reveals Lipids Intercalating Connexin Assemblies

Using single particle cryo-EM on plaque-mimicking nanodiscs, researchers determined multiple connexin assembly states and uncovered lipid-protein interactions that may help understand gap junction organization and function.

#structural-biology #cryosparc #cryo-em #discoveries

CryoSPARC Team

·July 8, 2026

Automated Workflows

Automated Workflows in CryoSPARC™

How to make use of one-click, automated data processing workflows that can provide equal or better results as manual processing

#structural-biology #cryosparc #cryo-em #automated-workflows #gpcr

CryoSPARC Team

·June 25, 2026

Discoveries

Scratching Beneath the Surface: Cryo-EM Guides New Opioid Drug Design

Cryo-EM revealed the molecular basis of KOR signaling bias, enabling structure-based drug design of an anti-pruritic peptide with reduced side effects.

#structural-biology #cryosparc #cryo-em #discoveries #sbdd #gpcr

CryoSPARC Team

·June 16, 2026

Case Studies

A Complex Story: A Case Study in Cryo-EM Heterogeneity

From active and deactive states to additional respiratory complexes, this case study shows how a single cryo-EM dataset can tell many different stories when viewed through the lens of heterogeneity.

#structural-biology #cryosparc #cryo-em #heterogeneity #case-study

CryoSPARC Team

·June 9, 2026