#structural-biology

8 posts with this tag.

Cryo-EM Reveals the Molecular Machinery of Tubulin Assembly

By capturing transient β-tubulin-bound intermediates with cryo-EM, researchers reconstructed the molecular mechanism of α/β-tubulin biogenesis, explaining how mutations in the assembly machinery lead to tubulin biogenesis disorders.

#structural-biology #cryosparc #cryo-em #discoveries

CryoSPARC Team

·July 30, 2026

Discoveries

Mind The Gap: Cryo-EM Reveals Lipids Intercalating Connexin Assemblies

Using single particle cryo-EM on plaque-mimicking nanodiscs, researchers determined multiple connexin assembly states and uncovered lipid-protein interactions that may help understand gap junction organization and function.

#structural-biology #cryosparc #cryo-em #discoveries

CryoSPARC Team

·July 8, 2026

Automated Workflows

Automated Workflows in CryoSPARC™

How to make use of one-click, automated data processing workflows that can provide equal or better results as manual processing

#structural-biology #cryosparc #cryo-em #automated-workflows #gpcr

CryoSPARC Team

·June 25, 2026

Discoveries

Scratching Beneath the Surface: Cryo-EM Guides New Opioid Drug Design

Cryo-EM revealed the molecular basis of KOR signaling bias, enabling structure-based drug design of an anti-pruritic peptide with reduced side effects.

#structural-biology #cryosparc #cryo-em #discoveries #sbdd #gpcr

CryoSPARC Team

·June 16, 2026

Case Studies

A Complex Story: A Case Study in Cryo-EM Heterogeneity

From active and deactive states to additional respiratory complexes, this case study shows how a single cryo-EM dataset can tell many different stories when viewed through the lens of heterogeneity.

#structural-biology #cryosparc #cryo-em #heterogeneity #case-study

CryoSPARC Team

·June 9, 2026