Case StudiesMixing Two Cryo-EM Datasets on Purpose: A Cryo-EM Heterogeneity ChallengeUsing a controlled FaNaC1 dataset, we compared 3D Classification, Heterogeneous Refinement, 3D Variability Analysis, and 3D Flexibility Analysis to explore practical strategies for resolving both discrete and continuous heterogeneity in cryo-EM.#structural-biology#cryosparc#cryo-em#heterogeneity#case-studyCryoSPARC Team·August 13, 2026
DiscoveriesCryo-EM Reveals the Molecular Machinery of Tubulin AssemblyBy capturing transient β-tubulin-bound intermediates with cryo-EM, researchers reconstructed the molecular mechanism of α/β-tubulin biogenesis, explaining how mutations in the assembly machinery lead to tubulin biogenesis disorders.#structural-biology#cryosparc#cryo-em#discoveriesCryoSPARC Team·July 30, 2026
Digging deeperDigging Deeper: Why refinements can be robust to the presence of junk particlesThe effect of parameter settings on 3D refinement: Minimize over per-particle scale, Adaptive marginalization, Non-uniform regularization, and Masking#cryosparc#cryo-em#refinement#methods#workflow#case-studyCryoSPARC Team·July 21, 2026
DiscoveriesMind The Gap: Cryo-EM Reveals Lipids Intercalating Connexin AssembliesUsing single particle cryo-EM on plaque-mimicking nanodiscs, researchers determined multiple connexin assembly states and uncovered lipid-protein interactions that may help understand gap junction organization and function.#structural-biology#cryosparc#cryo-em#discoveriesCryoSPARC Team·July 8, 2026
Automated WorkflowsAutomated Workflows in CryoSPARC™How to make use of one-click, automated data processing workflows that can provide equal or better results as manual processing#structural-biology#cryosparc#cryo-em#automated-workflows#gpcrCryoSPARC Team·June 25, 2026
DiscoveriesScratching Beneath the Surface: Cryo-EM Guides New Opioid Drug DesignCryo-EM revealed the molecular basis of KOR signaling bias, enabling structure-based drug design of an anti-pruritic peptide with reduced side effects.#structural-biology#cryosparc#cryo-em#discoveries#sbdd#gpcrCryoSPARC Team·June 16, 2026
Case StudiesA Complex Story: A Case Study in Cryo-EM HeterogeneityFrom active and deactive states to additional respiratory complexes, this case study shows how a single cryo-EM dataset can tell many different stories when viewed through the lens of heterogeneity.#structural-biology#cryosparc#cryo-em#heterogeneity#case-studyCryoSPARC Team·June 9, 2026
DiscoveriesA New Step in the Fight Against MeaslesHow Cryo-EM allows a closer look at the Human neutralizing antibodies targeting the measles virus#structural-biology#cryosparc#discoveries#cryo-emCryoSPARC Team·June 5, 2026
Small Protein TargetsThe Resolution Revolution Is Still OngoingHigh-Resolution Ab-Initio Reconstruction: Extending Cryo-EM to Smaller Particles with CryoSPARC™#structural-biology#cryosparc#cryo-em#small-proteinCryoSPARC Team·May 27, 2026
CryoSPARC UpdatesCryoSPARC v5.0 stable releaseExplore the new features, expanded capabilities, and a more intuitive processing experience!#structural-biology#cryosparc#release#overview#cryo-emCryoSPARC Team·May 27, 2026
