DiscoveriesMalaria Invasion at Molecular Resolution: From Protein Inhibitors to Membrane RemodelingUsing single-particle cryo-EM, researchers revealed how the malaria parasite's moving junction remodels host membranes and used its native structure to guide the design of a protein inhibitor of parasite invasion.#structural-biology#cryosparc#cryo-em#discoveries#sbddCryoSPARC Team·August 20, 2026
DiscoveriesCryo-EM Reveals the Molecular Machinery of Tubulin AssemblyBy capturing transient β-tubulin-bound intermediates with cryo-EM, researchers reconstructed the molecular mechanism of α/β-tubulin biogenesis, explaining how mutations in the assembly machinery lead to tubulin biogenesis disorders.#structural-biology#cryosparc#cryo-em#discoveriesCryoSPARC Team·July 30, 2026
DiscoveriesMind The Gap: Cryo-EM Reveals Lipids Intercalating Connexin AssembliesUsing single particle cryo-EM on plaque-mimicking nanodiscs, researchers determined multiple connexin assembly states and uncovered lipid-protein interactions that may help understand gap junction organization and function.#structural-biology#cryosparc#cryo-em#discoveriesCryoSPARC Team·July 8, 2026
DiscoveriesScratching Beneath the Surface: Cryo-EM Guides New Opioid Drug DesignCryo-EM revealed the molecular basis of KOR signaling bias, enabling structure-based drug design of an anti-pruritic peptide with reduced side effects.#structural-biology#cryosparc#cryo-em#discoveries#sbdd#gpcrCryoSPARC Team·June 16, 2026
DiscoveriesA New Step in the Fight Against MeaslesHow Cryo-EM allows a closer look at the Human neutralizing antibodies targeting the measles virus#structural-biology#cryosparc#discoveries#cryo-emCryoSPARC Team·June 5, 2026
